Gentiana lutea

Ponticelli, Maria, Lela, Ludovica, Moles, Mariapia, Mangieri, Claudia, Bisaccia, Donatella, Faraone, Immacolata, Falabella, Roberto & Milella, Luigi, 2023, The healing bitterness of Gentiana lutea L., phytochemistry and biological activities: A systematic review, Phytochemistry (113518) 206, pp. 1-27 : 15

3.6. Gentiana lutea L. effects on the central nervous system

In the last year, researchers have paid particular attention to discovering undescribed active principles from plants able to modulate nervous system functions and prevent neurological disorders. Compounds like iridoids have been reported to exert several beneficial effects on the central nervous system (CNS). Several studies have indeed demonstrated that iridoids like geniposide possess neuritogenic effects on neuronal cell cultures, probably thanks to their ability to activate protein kinase leading to neuronal cell differentiation induction ( Yamazaki et al., 1996). In this paragraph, the discoveries to date on the effect of G. lutea extract and its compounds on CNS will be treated.